Aplasia

Aplasia cutis congenitia is a hereditary skin disorder that causes patches of skin that deteriorate and leave abnormal open sores. These exposed lesions form spontaneously due to a normal cellular regeneration. This is rare condition. About 70% of reported cases have the lesion on the scalp. It appears as an exposed bloody patch of exposed subcutaneous tissue. These lesions caused by congenital aplasia of the skin leave the body dangerously vulnerable to infection. The lesions generally appear shortly after birth.

Medullary Aplasia is malformation or abnormal tissue regeneration of the medulla oblongata. The medulla oblongata controls almost all involuntary functions of the body. The medulla oblongata is located in the upper portion of the brain stem, towards the posterior. Chemoreceptors for respiratory rhythm are located on the medulla oblogata. The cardiac center is also located in the medulla oblongata, which works closely with the sympathetic and parasympathetic nervous systems. The medulla oblongata is also the control center for involuntary responses to stimulus such as coughing, sneezing, and swallowing. Medullary aplasia is a degenerative disease that causes death in many people who suffer from it. This is because the medulla is one of the centers of all vital bodily functions.

Sometimes applasia can be caused by certain drugs used to treat other diseases. Doctors have to watch for signs of applasia when performing drug treatments with drugs that have potential for aplastic side-effects. For example, a 1957 from the British Medical Journal suggests that persons with chronic myeloid leukemia who are being treated with the chemotherapy drug busulphan. Busulphan is usually traded under the brand name mylefan. It is a drug that is designed to stop the growth of cancer cells. Other chemotherapy drugs are often used in concert with busulphan. In patients suffering from chronic myeloid leukemia, the use of busulphan is linked to the incidence of medullary applasia. This is a dangerous and potentially fatal side effect. The chemotherapy drug causes an exaggerated therapeutic effect, which means that the drug stops or retard the regeneration of cells on the medulla, which could lead to serious or fatal complications. The drug has also been linked to marrow applasia. Marrow applasia is the malformation of bone marrow tissue. As all students of medicine and biology know, the bone marrow is the place in which the white blood cells are produced. Deformation, poor regeneration, or destruction of marrow means that the body cannot fight the cancer by itself.